node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ampC | mexA | PA4110 | PA0425 | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.825 |
ampC | mexB | PA4110 | PA0426 | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.887 |
ampC | oprD | PA4110 | PA0958 | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. | 0.883 |
ampC | oprJ | PA4110 | PA4597 | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.883 |
ampC | oprM | PA4110 | PA0427 | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.883 |
ampC | oprN | PA4110 | PA2495 | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.883 |
mexA | ampC | PA0425 | PA4110 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | 0.825 |
mexA | mexB | PA0425 | PA0426 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.999 |
mexA | oprD | PA0425 | PA0958 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. | 0.883 |
mexA | oprF | PA0425 | PA1777 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Major porin and structural outer membrane porin OprF precursor; Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. | 0.469 |
mexA | oprJ | PA0425 | PA4597 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.977 |
mexA | oprM | PA0425 | PA0427 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.999 |
mexA | oprN | PA0425 | PA2495 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.965 |
mexB | ampC | PA0426 | PA4110 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. | 0.887 |
mexB | mexA | PA0426 | PA0425 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.999 |
mexB | oprD | PA0426 | PA0958 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. | 0.885 |
mexB | oprJ | PA0426 | PA4597 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.988 |
mexB | oprM | PA0426 | PA0427 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.999 |
mexB | oprN | PA0426 | PA2495 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.978 |
oprB | oprD | PA3186 | PA0958 | Glucose/carbohydrate outer membrane porin OprB precursor; Substrate-selective channel for a variety of different sugars. Could potentially facilitate the diffusion of diverse compounds, dependent on the presence of a hydroxyl group, but is presumably restricted to carbohydrates. Involved in the transport of glucose, mannitol, fructose and glycerol (sugars able to support the growth of P.aeruginosa). Facilitates glucose diffusion across the outer membrane. | Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. | 0.935 |